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Aging (Aging-US) Research

Aging (Aging-US) Research

Aging-US Research

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Aging (Aging-US) Research

AMD
Aging Blog News Trending

Trending With Impact: Humanin G Treatment in AMD Reduces Inflammation

June 2, 2022August 2, 2022

In an Aging-US cover paper, researchers investigated a potential therapeutic intervention to reduce chronic inflammation in age-related macular degeneration (AMD).

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Figure 16. Influences of mutant and WT-TP53 on mitochondrial activity and glucose metabolism and effects of rapamycin and metformin. The effects of WT and mutant TP53 on key enzymes important in glycolysis and how they can influence metabolism and PDAC tumor growth. In our studies, we have examined the effect of GOF mutant TP53 and in some cases WT TP53. In addition, sites of interaction of the type 2 diabetes drug metformin and the immunosuppressive drug rapamycin and their effects on AMPK and mTORC1 are indicated. TP53 can induce mitochondrial apoptosis pathway by regulating the expression of PUMA and other proteins.
Aging Blog News

TP53 Restoration Sensitizes Pancreatic Cancer to Multiple Drugs

May 4, 2022May 30, 2022

In Aging’s Volume 14, Issue 8, cover paper, researchers found that the restoration of wild-type TP53 decreased pancreatic cancer cell resistance to various drugs, including rapamycin.

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PandaOmics Identifies Duel-Targets of Aging and Age-Related Diseases
Aging Blog News Trending

PandaOmics Identifies Dual-Targets of Aging and Age-Related Diseases

March 31, 2022April 20, 2022

Researchers used PandaOmics software to identify potential drug targets that could treat both aging and age-related diseases.

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Colorectal cancer
Aging Blog News Trending

Trending With Impact: Intestinal Balance, Colorectal Cancer and Muc4

March 17, 2022March 18, 2022

Researchers investigated the functional significance of Muc4 in intestinal homeostasis and colorectal cancer progression.

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Cognitive decline
Aging Blog News Trending

Trending With Impact: Cognitive Decline Predicted from Middle-Age

March 3, 2022March 4, 2022

Researchers investigated epigenetic and brain aging markers in middle-age for their potential to predict cognitive decline.

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Muscle tissue
Aging News Trending

Trending With Impact: Are Our Muscles Intrinsically Impaired by Aging?

January 20, 2022February 4, 2022

In a priority research paper published by Aging-US in January of 2022, researchers investigated aged muscle stem cells and their ability to sense and respond to mechanical cues.

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Figure 6. Matching of our CR-related DEGs evidenced to be regulated with aging with a curated human CR network.
Aging News

Aging and Circadian Rhythm: Does a Conserved Link Exist?

January 4, 2022February 4, 2022

In the cover paper published in Aging (Aging-US) Volume 13, Issue 24, researchers conducted a study suggesting that the circadian system is subjected to aging-related gene alterations.

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Figure 2. Altered mitochondrial morphology and activity in tauwt-expressing larvae. (Truncated)
Aging News Trending

Trending With Impact: Worms Reveal Early Event in Neurodegeneration

November 18, 2021February 4, 2022

Researchers examined roundworms to determine the role of mitochondrial dysfunction in progressive neurodegenerative disorders, such as Alzheimer’s disease.

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Algorithms
Aging News Trending

Trending With Impact: Machine Learning Predicts Human Aging

November 5, 2021February 4, 2022

Machine learning and a broad range of biochemical and physiological traits were used to develop a new composite metric as a potential proxy for an underlying whole-body aging mechanism.

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High quality green tea leaves
Aging News Trending

Trending With Impact: Green Tea Enhances Fitness and Lifespan in Worms

October 21, 2021February 4, 2022

The mechanisms and pathways involved in the health and aging benefits conveyed by green tea were investigated in C. elegans.

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