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Aging (Aging-US) Research

Aging (Aging-US) Research

Aging-US Research

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Aging (Aging-US) Research

Human skin layers
Aging Blog News

Unveiling Role of Cytoskeleton in Aging: Insights from Dermal Fibroblast Research

September 5, 2024September 5, 2024

In this study, researchers reinforce knowledge about an age-related alteration in the synthesis of major proteins linked to the migratory and contractile functions of dermal human fibroblasts.

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Volume 14, Issue 24
Aging Latest Issue

Associations of the APOE ε2 and ε4 alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer’s disease biomarkers

December 31, 2022December 31, 2022

Capturing the genetic architecture of Alzheimer’s disease (AD) is challenging because of the complex interplay of genetic and non-genetic factors in its etiology. It has been suggested that AD biomarkers may improve the characterization of AD pathology and its genetic architecture…

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microRNA illustration
Aging Blog News

Can microRNAs in the Bloodstream Signal Cognitive Decline?

September 21, 2022September 21, 2022

A new study compared circulating miRNAs and their association with cognitive function and decline among cognitively “normal” men.

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3 Domains of Well-Being Extend Elderly Mobility and Longevity
Aging Blog News Trending

3 Domains of Well-Being Extend Elderly Mobility and Longevity

August 18, 2022August 19, 2022

In the Volume 14, Issue 15, Aging cover paper, researchers hypothesized that multidimensional well-being may prolong mobility-limitation-free survival and longevity among older adults.

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AMD
Aging Blog News Trending

Trending With Impact: Humanin G Treatment in AMD Reduces Inflammation

June 2, 2022August 2, 2022

In an Aging-US cover paper, researchers investigated a potential therapeutic intervention to reduce chronic inflammation in age-related macular degeneration (AMD).

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Figure 16. Influences of mutant and WT-TP53 on mitochondrial activity and glucose metabolism and effects of rapamycin and metformin. The effects of WT and mutant TP53 on key enzymes important in glycolysis and how they can influence metabolism and PDAC tumor growth. In our studies, we have examined the effect of GOF mutant TP53 and in some cases WT TP53. In addition, sites of interaction of the type 2 diabetes drug metformin and the immunosuppressive drug rapamycin and their effects on AMPK and mTORC1 are indicated. TP53 can induce mitochondrial apoptosis pathway by regulating the expression of PUMA and other proteins.
Aging Blog News

TP53 Restoration Sensitizes Pancreatic Cancer to Multiple Drugs

May 4, 2022May 30, 2022

In Aging’s Volume 14, Issue 8, cover paper, researchers found that the restoration of wild-type TP53 decreased pancreatic cancer cell resistance to various drugs, including rapamycin.

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PandaOmics Identifies Duel-Targets of Aging and Age-Related Diseases
Aging Blog News Trending

PandaOmics Identifies Dual-Targets of Aging and Age-Related Diseases

March 31, 2022April 20, 2022

Researchers used PandaOmics software to identify potential drug targets that could treat both aging and age-related diseases.

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Colorectal cancer
Aging Blog News Trending

Trending With Impact: Intestinal Balance, Colorectal Cancer and Muc4

March 17, 2022March 18, 2022

Researchers investigated the functional significance of Muc4 in intestinal homeostasis and colorectal cancer progression.

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Cognitive decline
Aging Blog News Trending

Trending With Impact: Cognitive Decline Predicted from Middle-Age

March 3, 2022March 4, 2022

Researchers investigated epigenetic and brain aging markers in middle-age for their potential to predict cognitive decline.

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Muscle tissue
Aging News Trending

Trending With Impact: Are Our Muscles Intrinsically Impaired by Aging?

January 20, 2022February 4, 2022

In a priority research paper published by Aging-US in January of 2022, researchers investigated aged muscle stem cells and their ability to sense and respond to mechanical cues.

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