The MEND (Bredesen) protocol to treat neurodegeneration associated with Alzheimer’s disease was tested in a small cohort. In 2016, researchers followed up with objective results.
Aging (Aging-US) Research
![Aging's 2020 Impact Factor](https://aging-us.org/wp-content/uploads/2021/08/2021-Impact-Factor-Banner_V6-1-800x600.jpg)
In June 2021, Web of Science (Clarivate Analytics) released their 2020 JCR Impact Factor. Aging is pleased to report that our 2020 impact factor is 5.682.
![Figure 5. Neratinib and AR12 combine to reduce the expression of HSP90, HSP70, GRP78 and HSP27 via autophagy.](https://aging-us.org/wp-content/uploads/2021/08/Screen-Shot-2021-08-19-at-5.23.37-PM-1-800x600.png)
Researchers tested antiviral, anticancer, and immunosuppressive drug combinations that may aid in treating neurodegenerative disorders, including Alzheimer’s disease.
![Infusion drips with bottles of yellow albumin fluid.](https://aging-us.org/wp-content/uploads/2021/08/AdobeStock_409672048-1-800x600.jpeg)
From the University of California Berkeley and Apheresis Care Group, researchers discovered a method of “refreshing” blood that reverses some of the effects of aging.
![Figure 1. Mitochondrial DNA in extracellular vesicles and association with human aging.](https://aging-us.org/wp-content/uploads/2021/08/EV-mtDNA-01-1-800x600.png)
Authors from the National Institute on Aging wrote the editorial paper, “Mitochondria as extracellular vesicle cargo in aging.”
![Embryonic stem cell colony](https://aging-us.org/wp-content/uploads/2021/07/Senescence-01-1-800x600.png)
Researchers from the Campisi Lab discovered new insights while investigating Cdkn1a transcript variants 1 and 2.
![Figure 1. Cross-tissue accessibility.](https://aging-us.org/wp-content/uploads/2021/07/Screen-Shot-2021-07-22-at-3.29.28-PM-2-800x600.png)
Researchers from Harvard University and the Broad Institute wrote a theory article, published by Aging in 2021, and entitled, “Shifting epigenetic contexts influence regulatory variation and disease risk.”
![Figure 1. Relationship between aging and diseases. When growth is completed, growth-promoting pathways increase cellular and systemic functions and thus drive aging. This is a pre-pre-disease stage, slowly progressing to a pre-disease stage. Eventually, alterations reach clinical disease definition, associated with organ damage, loss of functions (functional decline), rapid deterioration and death.](https://aging-us.org/wp-content/uploads/2021/07/Screen-Shot-2021-07-13-at-12.22.07-PM-800x600.png)
In 2018, Dr. Mikhail Blagosklonny wrote a thought provoking theory article, entitled: “Disease or not, aging is easily treatable.”
What was found buried in the dirt on Easter Island in 1964 was a compound that would mystify aging researchers for the next 50 years.
![Smartwatch / Smartphone](https://aging-us.org/wp-content/uploads/2021/06/Resized-smart-phone-1-800x600.jpg)
Researchers trained and validated a deep learning neural network technology—the GeroSense Biological Age Acceleration (BAA) system—to extract health-associated features from wearable sensor data.