Mikhail Blagosklonny, M.D., Ph.D., has a recommendation for Altos Labs in his new research perspective, entitled, “Altos Labs and the quest for immortality: but can we live longer right now?”
Aging (Aging-US) Research
In Aging’s Volume 14, Issue 8, cover paper, researchers found that the restoration of wild-type TP53 decreased pancreatic cancer cell resistance to various drugs, including rapamycin.
TP53 is a master regulator of many signaling and apoptotic pathways involved in: aging, cell cycle progression, gene regulation, growth, apoptosis, cellular senescence, DNA repair, drug resistance, malignant transformation, metastasis, and metabolism. Most pancreatic cancers are classified as pancreatic ductal adenocarcinomas (PDAC)…
Insulin-like growth factor (IGF)-binding proteins (IGFBPs) are secretory proteins that regulate IGF signaling. In this study, the researchers investigated the role of IGFBP5 in replicative senescence in embryonic mouse fibroblasts (MEFs).
