Cell senescence has recently emerged as a potentially relevant pathogenic mechanism in fibrosing interstitial lung diseases (f-ILDs), particularly in idiopathic pulmonary fibrosis. The researchers hypothesized that senescent human fibroblasts may suffice to trigger a progressive fibrogenic reaction in the lung…

To screen for molecules that reverse cellular aging and rejuvenate human cells without altering the genome, researchers developed high-throughput cell-based assays that distinguish young from old and senescent cells, including transcription-based aging clocks and a real-time nucleocytoplasmic compartmentalization (NCC) assay…