Aging (Aging-US) Research
Cellular senescence is a stable state of cell cycle arrest that regulates tissue integrity and protects the organism from tumorigenesis. However, the accumulation of senescent cells during aging contributes to age-related pathologies…
Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail
Aging coincides with the accumulation of senescent cells within skeletal muscle that produce inflammatory products, known as the senescence-associated secretory phenotype, but the relationship of senescent cells to muscle atrophy is unclear…
A new study by researchers from Osaka University’s Graduate School of Dentistry investigated cellular senescence in periodontal tissue and disease—identifying promising therapeutic targets for preventing periodontitis in the elderly.