Blog Archives - Page 8 of 8 - Aging (Aging-US) Research

Figure 16. Influences of mutant and WT-TP53 on mitochondrial activity and glucose metabolism and effects of rapamycin and metformin. The effects of WT and mutant TP53 on key enzymes important in glycolysis and how they can influence metabolism and PDAC tumor growth. In our studies, we have examined the effect of GOF mutant TP53 and in some cases WT TP53. In addition, sites of interaction of the type 2 diabetes drug metformin and the immunosuppressive drug rapamycin and their effects on AMPK and mTORC1 are indicated. TP53 can induce mitochondrial apoptosis pathway by regulating the expression of PUMA and other proteins.

TP53 Restoration Sensitizes Pancreatic Cancer to Multiple Drugs

May 4, 2022May 30, 2022

In Aging’s Volume 14, Issue 8, cover paper, researchers found that the restoration of wild-type TP53 decreased pancreatic cancer cell resistance to various drugs, including rapamycin.

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Trending With Impact: Underlying Mechanisms of Replicative Senescence

April 21, 2022April 26, 2022

Published on the cover of Aging’s Volume 14, Issue 7, researchers conducted a new study investigating the role of IGFBP5 in replicative senescence.

Immunofluorescence detection of GRSF1 (green) and mitochondria (red) in proliferating myoblasts and differentiating myotubes. Arrowheads indicate GRSF1 signals; n=3. Scale bar, 50 μm.

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Protein Linked to Aging-Related Muscle Loss

April 13, 2022September 16, 2022

Researchers investigated the mitochondrial protein GRSF1 for its role in the physiology of skeletal muscle aging.

PandaOmics Identifies Duel-Targets of Aging and Age-Related Diseases

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PandaOmics Identifies Dual-Targets of Aging and Age-Related Diseases

March 31, 2022April 20, 2022

Researchers used PandaOmics software to identify potential drug targets that could treat both aging and age-related diseases.

Figure 1. The diagram shows sex-specific alterations in plasticity and memory and the associated changes in amyloid beta (Aβ) pathology and inflammatory response in APP/PS1 mice.

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Trending With Impact: How Biological Sex Impacts Alzheimer’s Disease

March 24, 2022March 25, 2022

Men and women are disproportionately impacted by Alzheimer’s disease (AD). Researchers investigated AD mice for potential sex differences in synaptic function.