Literature on the interaction between cellular senescence and the immune system is reviewed, with a focus on cellular senescence in lymphoid organs.
Aging (Aging-US) Research
![Blue synapse and neuron on a blue background. 3d rendering](https://aging-us.org/wp-content/uploads/2021/08/AdobeStock_220045014-scaled-2-800x600.jpeg)
The MEND (Bredesen) protocol to treat neurodegeneration associated with Alzheimer’s disease was tested in a small cohort. In 2016, researchers followed up with objective results.
![Infusion drips with bottles of yellow albumin fluid.](https://aging-us.org/wp-content/uploads/2021/08/AdobeStock_409672048-1-800x600.jpeg)
From the University of California Berkeley and Apheresis Care Group, researchers discovered a method of “refreshing” blood that reverses some of the effects of aging.
![Figure 1. Relationship between aging and diseases. When growth is completed, growth-promoting pathways increase cellular and systemic functions and thus drive aging. This is a pre-pre-disease stage, slowly progressing to a pre-disease stage. Eventually, alterations reach clinical disease definition, associated with organ damage, loss of functions (functional decline), rapid deterioration and death.](https://aging-us.org/wp-content/uploads/2021/07/Screen-Shot-2021-07-13-at-12.22.07-PM-800x600.png)
In 2018, Dr. Mikhail Blagosklonny wrote a thought provoking theory article, entitled: “Disease or not, aging is easily treatable.”
![Smartwatch / Smartphone](https://aging-us.org/wp-content/uploads/2021/06/Resized-smart-phone-1-800x600.jpg)
Researchers trained and validated a deep learning neural network technology—the GeroSense Biological Age Acceleration (BAA) system—to extract health-associated features from wearable sensor data.
![Figure 4. Brain regions with significant post hyperbaric oxygen therapy changes in cerebral blood flow.](https://aging-us.org/wp-content/uploads/2021/06/HBOT-brain-01-1.png)
Hyperbaric oxygen therapy (HBOT) provides significant benefits for patients who have suffered brain damage. In this 2020 study, researchers assessed the effects of HBOT among healthy aging participants.
![Vagus nerve with lungs, heart, stomach and digestive tract, medically illustration](https://aging-us.org/wp-content/uploads/2021/06/Vagus-Nerve-01-1-1.png)
Researchers from the University of Leeds and the University of Glasgow conducted a 2019 study on the effects of transcutaneous vagal nerve stimulation (tVNS) among participants 55 years of age and older.
![Figure 3. Morphological changes induced by long-term OSKM gene action in human umbilical cord perivascular cells (HUCPVC).](https://aging-us.org/wp-content/uploads/2021/05/Screen-Shot-2021-05-18-at-2.54.12-PM-1-800x600.png)
Researchers discuss the role that the epigenetic clock may play in the aging process and in rejuvenation as an approach to set back epigenetic age.
![Modern Medical Research Laboratory. Scientific Lab, Drug Engineering Center Full of High-Tech Equipment, Computer Screen Showing DNA concept, Technology for Vaccine Development.](https://aging-us.org/wp-content/uploads/2021/05/AdobeStock_416534436-scaled-1-800x600.jpeg)
In an effort to mimic metformin and rapamycin, researchers used powerful screening methods to analyze over 800 natural compounds to assess their anti-aging potential and safety profile.