Skip to content
Aging (Aging-US) Research

Aging (Aging-US) Research

Aging-US Research

  • Facebook
  • Twitter
  • Instagram
  • LinkedIn
  • YouTube
  • Pinterest
  • SoundCloud
  • Reddit
  • Home
  • News

Aging (Aging-US) Research

Figure 16. Influences of mutant and WT-TP53 on mitochondrial activity and glucose metabolism and effects of rapamycin and metformin. The effects of WT and mutant TP53 on key enzymes important in glycolysis and how they can influence metabolism and PDAC tumor growth. In our studies, we have examined the effect of GOF mutant TP53 and in some cases WT TP53. In addition, sites of interaction of the type 2 diabetes drug metformin and the immunosuppressive drug rapamycin and their effects on AMPK and mTORC1 are indicated. TP53 can induce mitochondrial apoptosis pathway by regulating the expression of PUMA and other proteins.
Aging Blog News

TP53 Restoration Sensitizes Pancreatic Cancer to Multiple Drugs

May 4, 2022May 30, 2022

In Aging’s Volume 14, Issue 8, cover paper, researchers found that the restoration of wild-type TP53 decreased pancreatic cancer cell resistance to various drugs, including rapamycin.

Read More
Radiation therapy, advanced medical linear accelerator in therapeutic oncology to treat cancer
Aging News Trending

Trending With Impact: Radiation, Senescence and Senotherapeutics

February 18, 2022February 20, 2022

Researchers investigated radiation-induced senescent cells and their effects on tumor growth, and senotherapeutics to mitigate these effects.

Read More
3D illustration of a mutated or damaged DNA strand
Aging News

Rapamycin Rules out DNA Damage Theory of Aging

May 5, 2021February 4, 2022

Dr. Mikhail Blagosklonny gleans an important new discovery in aging research—deduced from recent studies on short-lived mice and rapamycin.

Read More
Misha Blagosklonny News

Rapamycin Rules out DNA Damage Theory of Aging

April 21, 2021February 4, 2022

Dr. Mikhail Blagosklonny gleans an important new discovery in aging research—deduced from recent studies on short-lived mice and rapamycin.

Read More
  • twitter

Copyright © 2023 Impact Journals, LLC

Impact Journals is a registered trademark of Impact Journals, LLC