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Aging-US Research

Aging-US Research

Aging-US.org features weekly blog posts describing new and trending research papers published by Aging-US

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Aging-US Research

How Aging Leads to Chronic Disease: A Two-Stage Model
Aging Blog Misha Blagosklonny News

How Aging Leads to Chronic Disease: A Two-Stage Model

February 17, 2026February 17, 2026

Aging has long been explained in different ways. One traditional view is that it results from the gradual accumulation of molecular damage over time. Another perspective, based on evolutionary theory, suggests that natural selection strongly protects health during youth and reproductive years but becomes less effective later in life.

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Figure 1. Relationship between aging and diseases. When growth is completed, growth-promoting pathways increase cellular and systemic functions and thus drive aging. This is a pre-pre-disease stage, slowly progressing to a pre-disease stage. Eventually, alterations reach clinical disease definition, associated with organ damage, loss of functions (functional decline), rapid deterioration and death.
Aging News

Aging Is Easily Treatable

July 13, 2021February 4, 2022

In 2018, Dr. Mikhail Blagosklonny wrote a thought provoking theory article, entitled: “Disease or not, aging is easily treatable.”

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Aging News

Rapamycin: The Miracle Compound From Easter Island

July 8, 2021February 4, 2022

What was found buried in the dirt on Easter Island in 1964 was a compound that would mystify aging researchers for the next 50 years.

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